2XWT, 3G04
· G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
· cell-cell signaling
促甲状腺激素受体（英语：thyrotropin receptor，TSH receptor，TSHR）是一种接受促甲状腺激素（thyrotropin）信号，刺激细胞生成甲状腺激素（T4）和三碘甲状腺激素（T3）的跨膜受体。TSHR是膜内在蛋白（英语：Integral membrane protein）中G蛋白偶联受体超家族的一员，与Gs蛋白（英语：Gs alpha subunit）相连接。
该受体主要出现在甲状腺上皮细胞（英语：thyroid epithelial cell）的表面。
Upon binding circulating thyrotropin, a G-protein signal cascade activates adenylyl cyclase and intercellular levels of cAMP rise. cAMP activates all functional aspects of the thyroid cell, including iodine pumping; thyroglobulin synthesis, iodination, endocytosis and proteolysis; thyroid peroxidase activity; and hormone release.
