1D5R, 2KYL
· phosphatidylinositol-3-phosphatase activity
· phosphoprotein phosphatase activity
· protein serine/threonine phosphatase activity
· protein tyrosine phosphatase activity
· protein binding
· protein tyrosine/serine/threonine phosphatase activity
· lipid binding
· anaphase-promoting complex binding
· phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
· enzyme binding
· protein kinase binding
· PDZ domain binding
· inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
· cytoplasm
· cytosol
· plasma membrane
· internal side of plasma membrane
· PML body
· myelin sheath adaxonal region
· cell projection
· neuron projection
· angiogenesis
· negative regulation of protein phosphorylation
· regulation of B cell apoptotic process
· protein dephosphorylation
· phospholipid metabolic process
· phosphatidylinositol biosynthetic process
· apoptotic process
· induction of apoptosis
· activation of mitotic anaphase-promoting complex activity
· epidermal growth factor receptor signaling pathway
· neuron-neuron synaptic transmission
· synapse assembly
· central nervous system development
· heart development
· learning or memory
· locomotory behavior
· cell proliferation
· positive regulation of cell proliferation
· negative regulation of cell proliferation
· fibroblast growth factor receptor signaling pathway
· regulation of neuron projection development
· negative regulation of phosphatidylinositol 3-kinase cascade
· cell migration
· dentate gyrus development
· central nervous system neuron axonogenesis
· negative regulation of cell migration
· negative regulation of myelination
· regulation of protein stability
· negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S
· central nervous system myelin maintenance
· regulation of cellular component size
· regulation of myeloid cell apoptotic process
· multicellular organismal response to stress
· social behavior
· peptidyl-tyrosine dephosphorylation
· maternal behavior
· negative regulation of apoptotic process
· protein kinase B signaling cascade
· endothelial cell migration
· inositol phosphate metabolic process
· small molecule metabolic process
· innate immune response
· locomotor rhythm
· negative regulation of cell size
· negative regulation of organ growth
· inositol phosphate dephosphorylation
· phosphatidylinositol dephosphorylation
· neurotrophin TRK receptor signaling pathway
· phosphatidylinositol-mediated signaling
· cardiac muscle tissue development
· forebrain morphogenesis
· brain morphogenesis
· negative regulation of epithelial cell proliferation
· negative regulation of axonogenesis
· protein stabilization
· T cell receptor signaling pathway
· positive regulation of sequence-specific DNA binding transcription factor activity
· negative regulation of focal adhesion assembly
· negative regulation of protein kinase B signaling cascade
· rhythmic synaptic transmission
· canonical Wnt receptor signaling pathway
· synapse maturation
· prepulse inhibition
· male mating behavior
· long-term synaptic potentiation
· prostate gland growth
· dendritic spine morphogenesis
· negative regulation of dendritic spine morphogenesis
· negative regulation of ribosome biogenesis
· negative regulation of cell aging
· negative regulation of excitatory postsynaptic membrane potential
· presynaptic membrane assembly
· postsynaptic density assembly
· positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
· negative regulation of G1/S transition of mitotic cell cycle
· positive regulation of excitatory postsynaptic membrane potential
磷酸酯酶与张力蛋白同源物（英语：Phosphatase and tensin homolog，简称为PTEN）是一种在人体中由基因编码的蛋白质。该基因的突变是多种癌症进展过程的环节之一。
通过其磷酸酯酶蛋白产物而行使一种抑癌基因的作用。这一磷酸酯酶参与了细胞周期的调节，阻止细胞过快地生长与分裂。其为癌微RNAMIRN21的靶之一。
该基因被鉴定为一种肿瘤抑制物，在多种癌症中往往处于变异状态。该基因编码的蛋白质是一种磷脂酰肌醇-3,4,5-三磷酸3-磷酸酯酶。该蛋白同时含有一张力蛋白样结构域及一催化结构域，这与双特异性蛋白酪氨酸磷酸酶很相似。但与大部分蛋白质酪氨酸磷酸酶不同的是，该蛋白偏好脱去磷酸肌醇底物上的磷酸。该蛋白负性调控胞内磷脂酰肌醇-3,4,5-三磷酸的水平，并通过负性调控Akt/PKB信号通道发挥抑癌基因的作用。
PTEN (基因)引用了美国国家医学图书馆提供的资料，这些资料属于公共领域。
Template:蛋白酪氨酸磷酸酶类
脂酶（胆盐依赖性脂酶、胃脂肪酶/舌脂肪酶、胰脂肪酶、溶酶体酸性脂肪酶、激素敏感性脂肪酶、内皮脂肪酶、肝脂肪酶、脂蛋白脂肪酶、单酰基甘油脂肪酶、二酰基甘油脂肪酶）
磷脂酶（A1、A2、B）
· 2.1/2/3/4/5/6/7(2.7.10/11-12)/8/9 · 3.1/2/3/4(3.4.21/22/23/24)/5/6/7/8/9/10/11/12/13 ·
医学导航: 肿瘤
基因/标志
肿瘤/同名/附瘤
药物 (L1i/1e/V03)
