葡萄糖-6-磷酸脱氢酶

1QKI, 2BH9, 2BHL· binding · glucose binding · glucose binding · oxidoreductase activity · protein homodimerization activity· centrosome · cytosol · cytosol · internal side of plasma membrane· carbohydrate metabolic process · pentose-phosphate shunt · pentose-phosphate shunt · lipid metabolic process · cholesterol biosynthetic process · NADPH regeneration · glutathione metabolic process · pentose-phosphate shunt, oxidative branch · negative regulation of protein glutathionylation · pentose biosynthetic process · cellular response to oxidative stress · erythrocyte maturation · ribose phosphate biosynthetic process · glucose 6-phosphate metabolic process葡萄糖-6-磷酸脱氢酶（英语：glucose-6-phosphate dehydrogenase，EC 1.1.1.49）是一种以NAD+或NADP+为受体、作用于供体CH-OH基团上的氧化还原酶。这种酶能催化以下酶促反应：葡萄糖-6-磷酸脱氢酶主要参与磷酸戊糖途径，也能缓慢地作用在β-D-葡萄糖等其他糖类上。这种酶可由其底物葡萄糖-6-磷酸激活，如果人类表达葡萄糖-6-磷酸脱氢酶的基因G6PD有缺陷，将会导致葡萄糖-6-磷酸脱氢酶缺乏症，引发非免疫性溶血性贫血。葡萄糖-6-磷酸脱氢酶存在于众多生物细胞内，高等植物拥有数种葡萄糖-6-磷酸脱氢酶的蛋白异构体（protein isoform），它们分布于细胞质基质、和过氧化物酶体等细胞结构中。EC 1.1/2/3/4/5/6/7/8/9/10/11/12/13/14/15/16/17/18/19/20/21/22  · 2.1/2/3/4/5/6/7(2.7.10/11-12)/8/9  · 3.1/2/3/4(3.4.21/22/23/24)/5/6/7/8/9/10/11/12/13  ·