首页 >
血管收缩素I
✍ dations ◷ 2025-06-27 23:01:25 #血管收缩素I
1N9U, 1N9V, 2JP8, 2WXW, 2X0B· hormone activity
· hormone activity
· protein binding
· growth factor activity
· acetyltransferase activator activity
· type 1 angiotensin receptor binding· extracellular region
· extracellular region
· extracellular space
· extracellular space
· extracellular space
· soluble fraction· regulation of cell growth
· blood vessel development
· positive regulation of cytokine production
· kidney development
· blood vessel remodeling
· angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure
· renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure
· regulation of blood volume by renin-angiotensin
· renin-angiotensin regulation of aldosterone production
· regulation of renal output by angiotensin
· regulation of blood vessel size by renin-angiotensin
· brain renin-angiotensin system
· cellular sodium ion homeostasis
· cell-matrix adhesion
· G-protein coupled receptor protein signaling pathway
· G-protein signaling, coupled to cGMP nucleotide second messenger
· activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger
· nitric oxide mediated signal transduction
· cell-cell signaling
· excretion
· establishment of blood-nerve barrier
· regulation of blood pressure
· negative regulation of cell proliferation
· response to cold
· response to salt stress
· positive regulation of activation of JAK2 kinase activity
· positive regulation of endothelial cell migration
· positive regulation of cardiac muscle hypertrophy
· positive regulation of macrophage derived foam cell differentiation
· positive regulation of cholesterol esterification
· negative regulation of endopeptidase activity
· regulation of norepinephrine secretion
· positive regulation of phosphatidylinositol 3-kinase cascade
· response to muscle activity involved in regulation of muscle adaptation
· regulation of vasoconstriction
· regulation of proteolysis
· extracellular matrix organization
· negative regulation of cell growth
· peristalsis
· positive regulation of cellular protein metabolic process
· positive regulation of NAD(P)H oxidase activity
· low-density lipoprotein particle remodeling
· positive regulation of multicellular organism growth
· regulation of cell proliferation
· hormone metabolic process
· drinking behavior
· positive regulation of apoptosis
· positive regulation of catalytic activity
· positive regulation of MAPKKK cascade
· negative regulation of neuron apoptosis
· cellular lipid metabolic process
· positive regulation of fatty acid biosynthetic process
· positive regulation of epidermal growth factor receptor signaling pathway
· positive regulation of transcription, DNA-dependent
· positive regulation of organ growth
· astrocyte activation
· positive regulation of fibroblast proliferation
· regulation of long-term neuronal synaptic plasticity
· smooth muscle cell proliferation
· positive regulation of inflammatory response
· positive regulation of peptidyl-tyrosine phosphorylation
· positive regulation of NF-kappaB transcription factor activity
· smooth muscle cell differentiation
· negative regulation of nerve growth factor receptor signaling pathway
· positive regulation of protein tyrosine kinase activity
· positive regulation of branching involved in ureteric bud morphogenesis血管收缩素(Angiotensin),亦称血管紧张素、血管张力素,是一种寡肽类激素,是肾素-血管收缩素系统(renin-angiotensin system)的重要组成部分。血管紧张素能引起血管收缩,升高血压;促进肾上腺皮质释放醛固酮。它也具有很强的致渴作用。血管紧张素的前体是由肝脏合成的一种血清球蛋白:血管紧张素原。血管紧张素最早于20世纪30年代末由美国印第安纳和阿根廷的研究人员分别独立分离,并被分别命名为Angiotonin和Hypertensin,后来被美国克利夫兰诊所和瑞士巴塞尔的汽巴实验室(Ciba Laboratories)描述并合成。血管紧张素原是一种主要由肝脏持续合成并释放入血液循环的α-2球蛋白。它属于丝氨酸蛋白酶抑制物超家族(serine protease inhibitors,serpin),虽然就目前所知它不能抑制任何酶的活性。皮质激素、雌激素、甲状腺素和血管紧张素II可增高血浆血管紧张素原含量。血管紧张素原是肾素的底物。人血管紧张素原包含452个氨基酸残基,而其他物种的血管紧张素原大小有所不同。它的N-端12个氨基酸残基由于关系到其活性而最为重要。血管紧张素Ⅰ由肾素作用于血管紧张素原形成。肾素能催化血管紧张素原亮氨酸(Leu)与缬氨酸(Val)间的肽键水解产生十肽血管紧张素I;血管紧张素Ⅰ基本没有生物学活性,而是作为血管紧张素Ⅱ的前体存在。血管紧张素I经血管紧张素Ⅰ转化酶剪切C-末端两个氨基酸残基而形成血管紧张素Ⅱ。血管紧张素II是一种可通过内分泌、自分泌/旁分泌以及胞内分泌发挥作用的激素。血管紧张素Ⅱ通过血管紧张素酶降解为血管紧张素Ⅲ,其在循环系统的半衰期约为30秒,而在组织中最长可达15至30分钟。相比较血管紧张素Ⅱ而言,血管紧张素Ⅲ(七肽)仍具有40%的升压活性和100%的促醛固酮分泌活性。血管紧张素Ⅳ(六肽)与血管紧张素Ⅲ相似,而活性更低。Template:Angiotensin receptor modulators(英语:Template:Angiotensin receptor modulators)
相关
- 斜睾目见内文斜睾目(学名:Plagiorchiida)是吸虫纲复殖亚纲之下两个目之一。本目原来只是复殖亚纲之下五个目之一,但后来这些目现时大多成为了斜睾目之下的亚目。以下为部分本目的科:引
- 再生障碍性贫血再生不良性贫血(aplastic anemia/aplastic anaemia)也叫再生障碍性贫血(简称再障),是指骨髓未能生产足够或新的细胞来补充血液细胞的情况。一般来说,贫血是指低的红血球统计,但患有
- 酒石酸酒石酸(tartaric acid), C4H6O6,是一种α-羧酸, 双质子酸,存在于多种植物中,如葡萄,香蕉和罗望子,也是葡萄酒中主要的有机酸之一。通常与小苏打组合以充当面粉膨松剂。作为食品中
- 智慧设计论智能设计论(英语:Intelligent design,简称智设论、ID)是对神的存在的宗教性逻辑论证。尽管支持者认为智能设计论是一个“关于生命起源的科学理论”,但其已遭主流科学界视为伪科学
- 反射反射可以有以下含义:
- 罗德侯鲸罗德侯鲸(学名Rodhocetus)是一属已灭绝的鲸鱼,有着陆上哺乳动物的特征,显示了鲸鱼从陆地进入海洋的过渡性。第一个发现的物种是R. kasrani,它的盆骨已与脊骨及后肢融合,并有分化的
- abbr class=abbr title=R23/24/25: 吸入、触摸及吞食有毒R23/24/25/abbr警示性质标准词(英语:Risk Phrases,简写:R-phrases)是于《欧联指导标准67/548/EEC 附录III: 有关危险物品与其储备的特殊风险性质》里定义。该列表被集中并再出版于指导标准2001/
- 监护人监护人是指一个人在未成熟、经验不足或社会认为需要受监护的情况下对其进行指导和监督的人,尤其指避免监护对象行差踏错者。监护人不一定有法律地位。但一些政治人物的监护人
- 法瑞纳斯吉列尔莫·法里尼亚斯·埃尔南德斯(西班牙语:Guillermo Fariñas Hernández,1962年1月3日-),古巴心理医生、独立记者和持不同政见者。他多年来曾进行23次绝食以反抗古巴政权。他
- 法兰克福国际机场法兰克福机场(德语:Flughafen Frankfurt am Main或者Rhein-Main-Flughafen;IATA代码:FRA;ICAO代码:EDDF),一般也称作“莱茵-美因机场”,是位于德国黑森州法兰克福的一座民用机场。位