HER1/EGFR

1IVO, 1M14, 1M17, 1MOX, 1NQL, 1XKK, 1YY9, 1Z9I, 2EB2, 2EB3, 2GS2, 2GS7, 2ITN, 2ITO, 2ITP, 2ITQ, 2ITT, 2ITU, 2ITV, 2ITW, 2ITX, 2ITY, 2ITZ, 2J5E, 2J5F, 2J6M, 2JIT, 2JIU, 2JIV, 2KS1, 2M0B, 2M20, 2RF9, 2RFD, 2RFE, 2RGP, 3B2U, 3B2V, 3BEL, 3BUO, 3C09, 3G5V, 3G5Y, 3GOP, 3GT8, 3IKA, 3LZB, 3NJP, 3OB2, 3OP0, 3P0Y, 3PFV, 3POZ, 3QWQ, 3UG1, 3UG2, 3VJN, 3VJO, 3VRP, 3VRR, 3W2O, 3W2P, 3W2Q, 3W2R, 3W2S, 3W32, 3W33, 4G5J, 4G5P, 4HJO, 4I1Z, 4I20, 4I21, 4I22, 4I23, 4I24, 4JQ7, 4JQ8, 4JR3, 4JRV, 4KRL, 4KRM, 4KRO, 4KRP, 4LI5, 4LL0· MAP kinase kinase kinase activity · protein tyrosine kinase activity · transmembrane receptor protein tyrosine kinase activity · receptor signaling protein tyrosine kinase activity · transmembrane signaling receptor activity · epidermal growth factor-activated receptor activity · protein binding · ATP binding · enzyme binding · protein phosphatase binding · nitric-oxide synthase regulator activity · identical protein binding · protein heterodimerization activity· extracellular space · nucleus · cytoplasm · endosome · endoplasmic reticulum membrane · plasma membrane · endosome membrane · membrane · integral to membrane · basolateral plasma membrane · AP-2 adaptor complex · nuclear membrane · membrane raft · perinuclear region of cytoplasm· activation of MAPKK activity · ossification · embryonic placenta development · hair follicle development · response to stress · signal transduction · cell surface receptor signaling pathway · epidermal growth factor receptor signaling pathway · activation of phospholipase C activity · axon guidance · salivary gland morphogenesis · cell proliferation · positive regulation of cell proliferation · fibroblast growth factor receptor signaling pathway · cell-cell adhesion · cerebral cortex cell migration · positive regulation of cell migration · positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S · positive regulation of catenin import into nucleus · negative regulation of epidermal growth factor receptor signaling pathway · negative regulation of protein catabolic process · positive regulation of phosphorylation · activation of phospholipase A2 activity by calcium-mediated signaling · negative regulation of apoptotic process · positive regulation of MAP kinase activity · innate immune response · positive regulation of nitric oxide biosynthetic process · positive regulation of DNA repair · positive regulation of DNA replication · protein autophosphorylation · neurotrophin TRK receptor signaling pathway · phosphatidylinositol-mediated signaling · positive regulation of fibroblast proliferation · digestive tract morphogenesis · positive regulation of epithelial cell proliferation · regulation of peptidyl-tyrosine phosphorylation · regulation of nitric-oxide synthase activity · protein insertion into membrane · positive regulation of protein kinase B signaling cascade · morphogenesis of an epithelial fold表皮生长因子受体（英语：epidermal growth factor receptor，简称为EGFR、ErbB-1或HER1）是一类名为表皮生长因子家族（EGF-家族）的细胞外蛋白配体的细胞表面受体 。表皮生长因子受体是ErbB受体家族家族的成员之一，ErbB家族是包含四种紧密联系蛋白的亚家族，这四种蛋白分别是受体酪氨酸激酶类：EGFR（ErbB-1）、HER2/c-neu（ErbB-2）、Her 3（ErbB-3）以及Her 4（ErbB-4）。影响EGFR表达或活性的突变可能导致癌症。表皮生长因子及其受体是由范德堡大学的斯坦利·科恩发现的，科恩与丽塔·列维-蒙塔尔奇尼因发现生长因子类而共同获得了1986年诺贝尔生理学或医学奖。表皮生长因子受体（EGFR）存在于细胞表面且因结合特异性受体而被激活，这些受体包括表皮生长因子和转化生长因子-α。ErbB2并无已知的直接激活配体，可能结构性地处于激活状态，或在与如EGFR等其他家族成员形成异源二聚体时被激活。EC 1.1/2/3/4/5/6/7/8/9/10/11/12/13/14/15/16/17/18/19/20/21/22  · 2.1/2/3/4/5/6/7(2.7.10/11-12)/8/9  · 3.1/2/3/4(3.4.21/22/23/24)/5/6/7/8/9/10/11/12/13  ·医学导航: 肿瘤基因/标志肿瘤/同名/附瘤药物 (L1i/1e/V03)神经生长因子受体：高亲和力Trk受体 (TrkA, TrkB, TrkC)肝细胞生长因子受体（英语：C-Met）Somatomedin（胰岛素样生长因子1受体）ErbB/表皮生长因子受体