芳基硫酸酯酶A

1AUK, 1E1Z, 1E2S, 1E33, 1E3C, 1N2K, 1N2L, 2AIJ, 2AIK, 2HI8· cerebroside-sulfatase activity · calcium ion binding· extracellular space · lysosome · endosome · endoplasmic reticulum lumen · integral component of membrane · extrinsic component of external side of plasma membrane · lysosomal lumen· glycosphingolipid metabolic process · autophagy · binding of sperm to zona pellucida · central nervous system development · response to nutrient · response to pH · response to estrogen · post-translational protein modification · cellular protein metabolic process · small molecule metabolic process · response to ethanol芳基硫酸酯酶A(Arylsulfatase A、ARSA、酰基硫酸酯酶A、脑苷硫酸酯酶/cerebroside-sulfatase、芳香基硫酸酯酶A)属于酶之一种，它可以分解脑硫脂(sulfatide)，即分解"脑苷3硫酸"(cerebroside 3-sulfate)为脑苷脂及硫酸盐。在人类中，芳基硫酸酯酶A由ARSA基因编码。ARSA缺乏症与异染性脑白质退化症(MLD)有关，属常染色体隐性遗传疾病。芳基硫酸酯酶A被磷酸盐所抑制，从而与活性位点"3-甲酰甘氨酸"(3-formylglycine/3-oxoalanine)形成一个共价键。脂酶（胆盐依赖性脂酶、胃脂肪酶/舌脂肪酶、胰脂肪酶、溶酶体酸性脂肪酶、激素敏感性脂肪酶、内皮脂肪酶、肝脂肪酶、脂蛋白脂肪酶、单酰基甘油脂肪酶、二酰基甘油脂肪酶）磷脂酶（A1、A2、B）EC 1.1/2/3/4/5/6/7/8/9/10/11/12/13/14/15/16/17/18/19/20/21/22  · 2.1/2/3/4/5/6/7(2.7.10/11-12)/8/9  · 3.1/2/3/4(3.4.21/22/23/24)/5/6/7/8/9/10/11/12/13  ·Template:Glycolipid and sphingolipid metabolism enzymes（英语：Template:Glycolipid and sphingolipid metabolism enzymes）