核黄素

结构 / ECOD结构 / ECOD核黄素激酶（英语：riboflavin kinase，EC 2.7.1.26）是一个催化以下化学反应的酶：该酶催化的反应的底物为ATP和核黄素，产物是ADP和黄素单核苷酸（FMN）。但是，在古菌核黄素激酶（EC 2.7.1.161）中，常使用CTP而非ATP作为反应底物，催化如下反应：核黄素激酶也在许多细菌中发现，具有类似的功能，但存在若干数量的氨基酸不同。+ XTP → + XDPRiboflavin is converted into catalytically active cofactors (FAD and FMN) by the actions of riboflavin kinase (EC 2.7.1.26), which converts it into FMN, and FAD synthetase (EC 2.7.7.2), which adenylates FMN to FAD. Eukaryotes usually have two separate enzymes, while most prokaryotes have a single bifunctional protein that can carry out both catalyses, although exceptions occur in both cases. While eukaryotic monofunctional riboflavin kinase is orthologous to the bifunctional prokaryotic enzyme, the monofunctional FAD synthetase differs from its prokaryotic counterpart, and is instead related to the PAPS-reductase family. The bacterial FAD synthetase that is part of the bifunctional enzyme has remote similarity to nucleotidyl transferases and, hence, it may be involved in the adenylylation reaction of FAD synthetases.This enzyme belongs to the family of transferases, to be specific, those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:riboflavin 5'-phosphotransferase. This enzyme is also called flavokinase. This enzyme participates in riboflavin metabolism.截止2007年底，这类酶中已有14个三级结构被解决，在PDB的登陆代码为1N05，1N06，1N07，1N08，1NB0，1NB9，1P4M，1Q9S，2P3M，2VBS，2VBT，3CTA，2VBU，2VBV。医学导航：营养学辅助、代谢、微量元素病理、失调、症状／人名、先天药物（A8/11/12）EC 1.1/2/3/4/5/6/7/8/9/10/11/12/13/14/15/16/17/18/19/20/21/22  · 2.1/2/3/4/5/6/7(2.7.10/11-12)/8/9  · 3.1/2/3/4(3.4.21/22/23/24)/5/6/7/8/9/10/11/12/13  ·此条目包含有源于Pfam以及InterPro的属于公有领域的文本 IPR015865