2010年至2011年德国足球乙级联赛（德语：2010–11 2. Fußball-Bundesliga）是德国足球联赛第二级的德国足球乙级联赛的第37个赛季，于2010年8月21日周未展开，直到2011年5月15日结束。歇冬期由2010年12月18日周未至2011年1月15日。
As in the previous year, the league comprise the teams placed fourth through fifteenth of the 2009–10 season, the worst two teams from the 2009–10 Bundesliga, the best two teams from the 2009–10 3rd Liga, the losers of the Bundesliga relegation play-off between the 16th-placed Bundesliga team and the third-placed 2nd Bundesliga team and the winners of the 2nd Bundesliga relegation play-off between the 16th-placed 2nd Bundesliga team and the third-placed 3rd Liga team.
2009–10 2. Fußball-Bundesliga champions 1. FC Kaiserslautern, and runners-up FC St. Pauli were promoted to the Bundesliga. They were replaced by VfL Bochum and Hertha BSC who finished 17th and 18th respectively in the 2009–10 Bundesliga season.
TuS Koblenz and Rot-Weiß Ahlen were relegated after the 2009–10 season. They were replaced by 2009–10 3rd Liga champions VfL Osnabrück and runners-up FC Erzgebirge Aue.
Two further spots were available through relegation/promotion play-offs and taken by FC Augsburg and FC Ingolstadt 04. Augsburg lost in their promotion play-off against 16th placed Bundesliga team 1. FC Nuremberg and thus retained their 2. Bundesliga spot, while Ingolstadt earned promotion from the 3rd Liga by defeating FC Hansa Rostock.
因戈尔施塔特本季迁入新建的奥迪体育公园（Audi Sportpark）。杜塞尔多夫的思捷环球竞技场（Esprit Arena）将部分坐席改为立席，容量由51,500增加至54,400。同时菲尔特和杜伊斯堡的球场因获得新的冠名赞助而更名。
备注：
升级到德甲
获得参赛资格：升级附加赛
获得参赛资格：降级附加赛
降级到德丙
资料来源：bundesliga.de
排名规例：
1).积分；2).净胜差；3).进球。
1 1860 Munich were deducted two points because of providing insufficient information during the licensing process previous to this season.
2 Arminia Bielefeld were deducted three points because of accessing league security funds worth €1.25M.
（冠） = 冠军； （降） = 降级； （升） = 升级； (附) = 附加赛胜者； (晋) = 进入下一轮。
只在赛季仍进行中使用：
(参) = 获得指定竞赛参赛权； (TQ) = 获得竞赛参赛权，未知指定轮次； (DQ) = 取消竞赛参赛权。
资料来源︰Bundesliga
- 主场球队列于左方字段。
- 蓝色︰主场球队取胜；黄色︰战平；红色︰作客球队取胜。
奥斯纳布吕克排于本季联赛榜第16位，需要面对德丙排第3位的德雷斯顿迪纳摩进行两回合附加赛决定来季最后一个德乙席位谁属。德雷斯顿迪纳摩首回合主场，累计4-2胜出。
德雷斯顿迪纳摩 v 奥斯纳布吕克
奥斯纳布吕克 v 德雷斯顿迪纳摩
德雷斯顿迪纳摩累计4-2获胜；德雷斯顿迪纳摩升级德乙，而奥斯纳布吕克则降级德丙
