CCND1

2W96, 2W99, 2W9F, 2W9Z· protein binding · cyclin-dependent protein serine/threonine kinase regulator activity · enzyme binding · protein kinase binding· intracellular · nucleus · nucleoplasm · cytosol · tight junction· G1/S transition of mitotic cell cycle · S phase of mitotic cell cycle · mitotic cell cycle · re-entry into mitotic cell cycle · liver development · positive regulation of protein phosphorylation · response to DNA damage stimulus · lactation · response to iron ion · response to X-ray · response to organic nitrogen · negative regulation of Wnt receptor signaling pathway · negative regulation of epithelial cell differentiation · endoplasmic reticulum unfolded protein response · organ regeneration · mitotic G1 DNA damage checkpoint · response to magnesium ion · response to vitamin E · Leydig cell differentiation · mammary gland epithelial cell proliferation · positive regulation of mammary gland epithelial cell proliferation · response to drug · response to estrogen stimulus · fat cell differentiation · response to ethanol · positive regulation of cyclin-dependent protein kinase activity · cell division · response to corticosterone stimulus · response to calcium ion · canonical Wnt receptor signaling pathway · mammary gland alveolus development · response to UV-AG1/S-特异性周期蛋白-D1是一个由人类CCND1基因所编码的蛋白质。该基因编码的蛋白质属于高度保守的周期蛋白家族，该家族成员的显著特征是贯穿细胞周期，其蛋白质丰度周期性地急剧改变。周期蛋白作为CDK（周期蛋白依赖性激酶）的调节因子。不同的周期蛋白表现出各自独特的表达及降解特性，这有助于每个有丝分裂事件在时间上的协调性。周期蛋白D1这种亚型的周期蛋白与CDK4或CDK6形成复合物并作为它们的调节亚基，这两种周期蛋白依赖性激酶对于G1到S期的转变来说是不可或缺的。该蛋白表现出与抑癌基因Rb有着相互作用，且此基因的表达受Rb的正向调控。周期蛋白D1发生突变、扩增及过表达将会改变细胞周期进程，这些现象常发生在多种肿瘤中并可能导致肿瘤发生。使用周期蛋白D1进行免疫组化染色可用于诊断套细胞淋巴瘤。