MLL

2AGH, 2J2S, 2JYI, 2KKF, 2KU7, 2KYU, 2LXS, 2LXT, 2W5Y, 2W5Z, 3EG6, 3EMH, 3LQH, 3LQI, 3LQJ, 3P4F, 3U85, 3U88, 4ESG, 4GQ6· sequence-specific DNA binding transcription factor activity · protein binding · zinc ion binding · histone methyltransferase activity (H3-K4 specific) · identical protein binding · protein homodimerization activity · transcription regulatory region DNA binding · unmethylated CpG binding· histone methyltransferase complex· protein complex assembly · apoptotic process · positive regulation of transporter activity · embryonic hemopoiesis · histone H4-K16 acetylation · positive regulation of transcription, DNA-dependent · positive regulation of transcription from RNA polymerase II promoter · histone H3-K4 methylation · histone H3-K4 trimethylation组蛋白-赖氨酸N-甲基转移酶HRX（英语：Histone-lysine N-methyltransferase HRX）是人体中由MLL（ALL1）基因编码的一种酶。MLL代表髓样/淋巴样，或混合世系白血病。MLL是一种组蛋白甲基转移酶，被认为是影响基因转录的全局正向调控物。该蛋白属于组蛋白修饰酶类家族，包含了转活化结构域9aaTAD，且参与了对转录记忆的表观遗传学维持。MLL基因若发生重排（即染色体结构改变造成遗传物质的重新排列）则会导致严重的急性白血病，包括淋巴母细胞性及髓性。该基因亦可能参与了精神分裂症中GAD67表达下调的过程。现已显示MLL这个基因与HDAC1、PPP1R15A、宿主细胞因子C1、MEN1 RBBP5, ASH2L,、CREB结合蛋白、WDR5 CTBP1及PPIE.之间有着相互作用。