RB1

✍ dations ◷ 2025-06-28 05:57:50 #RB1
1AD6, 1GH6, 1GUX, 1H25, 1N4M, 1O9K, 1PJM, 2AZE, 2QDJ, 2R7G, 3N5U, 3POM, 4ELJ, 4ELL· RNA polymerase II activating transcription factor binding · DNA binding · sequence-specific DNA binding transcription factor activity · transcription coactivator activity · protein binding · transcription factor binding · kinase binding · ubiquitin protein ligase binding · androgen receptor binding· nucleus · nucleoplasm · spindle · SWI/SNF complex · PML body· G1 phase of mitotic cell cycle · G1/S transition of mitotic cell cycle · regulation of transcription involved in G1/S phase of mitotic cell cycle · S phase of mitotic cell cycle · mitotic cell cycle · chromatin remodeling · transcription, DNA-dependent · negative regulation of protein kinase activity · cell cycle arrest · mitotic cell cycle checkpoint · Ras protein signal transduction · regulation of mitotic cell cycle · virus-host interaction · androgen receptor signaling pathway · sister chromatid biorientation · neuron projection development · maintenance of mitotic sister chromatid cohesion · neuron maturation · enucleate erythrocyte differentiation · negative regulation of sequence-specific DNA binding transcription factor activity · regulation of lipid kinase activity · myoblast differentiation · positive regulation of macrophage differentiation · negative regulation of S phase of mitotic cell cycle · positive regulation of mitotic metaphase/anaphase transition · negative regulation of smoothened signaling pathway · negative regulation of transcription, DNA-dependent · positive regulation of transcription, DNA-dependent · positive regulation of transcription from RNA polymerase II promoter · digestive tract development · cell morphogenesis involved in neuron differentiation · negative regulation of epithelial cell proliferation · striated muscle cell differentiation · cell division · neuron apoptotic process · protein localization to chromosome, centromeric region · regulation of cohesin localization to chromatin · negative regulation of transcription involved in G1/S phase of mitotic cell cycle视网膜母细胞瘤蛋白(英语:retinoblastoma protein,常缩写为Rb、RB或RB1)又译为成视网膜细胞瘤蛋白是一种抑癌蛋白,并在几种主要的癌症发生时失活。Rb的功能之一是通过抑制细胞周期进程直到细胞准备妥当来防止细胞过度生长。当细胞准备好要分裂时,Rb蛋白会被磷酸化为pRb而失去抑制活性,从而使细胞周期进行下去。Rb是袋状蛋白家族的一员,其特点是有一个口袋状的结构用以结合其它蛋白。使得一些致癌变蛋白,比如高危险群人类乳突病毒所感染的细胞产生的蛋白,结合并抑制pRb,最终导致癌症。Rb restricts the cell's ability to replicate DNA by preventing its progression from the G1 (first gap phase) to S (synthesis phase) phase of the cell division cycle.。Rb结合并抑制E2F(英语:E2F)家族的转录因子,which are composed of dimers of an E2F protein and a dimerization partner (DP) protein. The transcription activating complexes of E2 promoter-binding–protein-dimerization partners (E2F-DP) can push a cell into S phase. As long as E2F-DP is inactivated, the cell remains stalled in the G1 phase. When Rb is bound to E2F, the complex acts as a growth suppressor and prevents progression through the cell cycle. The Rb-E2F/DP complex also attracts a histone deacetylase (HDAC) protein to the chromatin, reducing transcription of S phase promoting factors, further suppressing DNA synthesis.已知Rb蛋白与下列蛋白质有相互作用关系:视网膜母细胞瘤蛋白引用了美国国家医学图书馆提供的资料,这些资料属于公共领域。医学导航: 肿瘤基因/标志肿瘤/同名/附瘤药物 (L1i/1e/V03)

相关

  • 退伍军人菌嗜肺军团菌是一种有鞭毛,革兰氏阴性,军团菌属多形态性的短小球杆菌。嗜肺军团菌是一种原发的人类病原体,会引发军团病。嗜肺军团菌不抗酸,无孢子,无荚膜,类似于杆菌。不能分解明胶
  • 纤维化间质性肺病(Interstitial Lung Disease(ILD),又称为弥漫性肺病 Diffuse Parenchymal Lung Disease(DPLD))是一群主要侵犯肺泡上皮细胞,肺微血管内皮细胞、基底膜以及肺内血管及淋巴
  • 伊比利亚-罗曼语支伊比利亚罗曼语支(Iberian Romance languages) 是指罗曼语族中发展于伊比利亚半岛的语言,起源范围包括西班牙、葡萄牙、直布罗陀、安道尔和法国南部。最具代表性的伊比利亚罗曼
  • 原子序原子序数(英语:Atomic Number)是一个原子核内质子的数量,因此也称质子数,也等于原子电中性时的核外电子数。拥有同一原子序的原子属于同一化学元素。原子序数的符号是Z。通常原子
  • 肯塔基坐标:37°50′22″N 84°16′12″W / 37.8393332°N 84.2700179°W / 37.8393332; -84.2700179肯塔基州(英语:Commonwealth of Kentucky)是美国中东部的一个州,正式名称为肯塔基
  • 张道陵张道陵(34年-156年),一名张陵,字辅汉,东汉沛国丰县(今江苏徐州市丰县)人,被视为正一道的创始者,是五斗米道的创始人。道教徒称他为张道陵天师、祖天师、正一真人。相传张道陵以虎为座
  • 张本渝张本渝(Jessie Chang,1976年1月27日-)本名张本瑜,台湾女艺人。具有四分之一的台东阿美族血统。2013年1月30日凌晨驾车不慎追撞前车,对方坚持找警察处理。张本渝强调没酒驾,只有吃药
  • 戴姆勒name = 'Transport', description = '交通', content = {{ type = 'text', text = [[]] }, { type = 'item', original = 'articulated bus', rule = 'zh-cn:铰接客车;zh-tw
  • 东京奥运会除特别注明外,本文所有时间均以东九区时间(UTC+9)为准。本条目记叙2019冠状病毒病疫情对第32届夏季奥林匹克运动会的影响。受疫情影响,众多东京奥运会预选赛延期或被取消。2020
  • 急性粒细胞白血病急性骨髓性白血病(Acute myeloid leukemia,AML),是一种骨髓性造血芽球(而非淋巴性芽细胞)异常增殖的血液恶性肿瘤,是白血病的一种。其特点是骨髓内异常芽球的快速增殖而影响了正常