首页 >
血管紧张素II
✍ dations ◷ 2025-09-13 11:49:39 #血管紧张素II
1N9U, 1N9V, 2JP8, 2WXW, 2X0B· hormone activity
· hormone activity
· protein binding
· growth factor activity
· acetyltransferase activator activity
· type 1 angiotensin receptor binding· extracellular region
· extracellular region
· extracellular space
· extracellular space
· extracellular space
· soluble fraction· regulation of cell growth
· blood vessel development
· positive regulation of cytokine production
· kidney development
· blood vessel remodeling
· angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure
· renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure
· regulation of blood volume by renin-angiotensin
· renin-angiotensin regulation of aldosterone production
· regulation of renal output by angiotensin
· regulation of blood vessel size by renin-angiotensin
· brain renin-angiotensin system
· cellular sodium ion homeostasis
· cell-matrix adhesion
· G-protein coupled receptor protein signaling pathway
· G-protein signaling, coupled to cGMP nucleotide second messenger
· activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger
· nitric oxide mediated signal transduction
· cell-cell signaling
· excretion
· establishment of blood-nerve barrier
· regulation of blood pressure
· negative regulation of cell proliferation
· response to cold
· response to salt stress
· positive regulation of activation of JAK2 kinase activity
· positive regulation of endothelial cell migration
· positive regulation of cardiac muscle hypertrophy
· positive regulation of macrophage derived foam cell differentiation
· positive regulation of cholesterol esterification
· negative regulation of endopeptidase activity
· regulation of norepinephrine secretion
· positive regulation of phosphatidylinositol 3-kinase cascade
· response to muscle activity involved in regulation of muscle adaptation
· regulation of vasoconstriction
· regulation of proteolysis
· extracellular matrix organization
· negative regulation of cell growth
· peristalsis
· positive regulation of cellular protein metabolic process
· positive regulation of NAD(P)H oxidase activity
· low-density lipoprotein particle remodeling
· positive regulation of multicellular organism growth
· regulation of cell proliferation
· hormone metabolic process
· drinking behavior
· positive regulation of apoptosis
· positive regulation of catalytic activity
· positive regulation of MAPKKK cascade
· negative regulation of neuron apoptosis
· cellular lipid metabolic process
· positive regulation of fatty acid biosynthetic process
· positive regulation of epidermal growth factor receptor signaling pathway
· positive regulation of transcription, DNA-dependent
· positive regulation of organ growth
· astrocyte activation
· positive regulation of fibroblast proliferation
· regulation of long-term neuronal synaptic plasticity
· smooth muscle cell proliferation
· positive regulation of inflammatory response
· positive regulation of peptidyl-tyrosine phosphorylation
· positive regulation of NF-kappaB transcription factor activity
· smooth muscle cell differentiation
· negative regulation of nerve growth factor receptor signaling pathway
· positive regulation of protein tyrosine kinase activity
· positive regulation of branching involved in ureteric bud morphogenesis血管收缩素(Angiotensin),亦称血管紧张素、血管张力素,是一种寡肽类激素,是肾素-血管收缩素系统(renin-angiotensin system)的重要组成部分。血管紧张素能引起血管收缩,升高血压;促进肾上腺皮质释放醛固酮。它也具有很强的致渴作用。血管紧张素的前体是由肝脏合成的一种血清球蛋白:血管紧张素原。血管紧张素最早于20世纪30年代末由美国印第安纳和阿根廷的研究人员分别独立分离,并被分别命名为Angiotonin和Hypertensin,后来被美国克利夫兰诊所和瑞士巴塞尔的汽巴实验室(Ciba Laboratories)描述并合成。血管紧张素原是一种主要由肝脏持续合成并释放入血液循环的α-2球蛋白。它属于丝氨酸蛋白酶抑制物超家族(serine protease inhibitors,serpin),虽然就目前所知它不能抑制任何酶的活性。皮质激素、雌激素、甲状腺素和血管紧张素II可增高血浆血管紧张素原含量。血管紧张素原是肾素的底物。人血管紧张素原包含452个氨基酸残基,而其他物种的血管紧张素原大小有所不同。它的N-端12个氨基酸残基由于关系到其活性而最为重要。血管紧张素Ⅰ由肾素作用于血管紧张素原形成。肾素能催化血管紧张素原亮氨酸(Leu)与缬氨酸(Val)间的肽键水解产生十肽血管紧张素I;血管紧张素Ⅰ基本没有生物学活性,而是作为血管紧张素Ⅱ的前体存在。血管紧张素I经血管紧张素Ⅰ转化酶剪切C-末端两个氨基酸残基而形成血管紧张素Ⅱ。血管紧张素II是一种可通过内分泌、自分泌/旁分泌以及胞内分泌发挥作用的激素。血管紧张素Ⅱ通过血管紧张素酶降解为血管紧张素Ⅲ,其在循环系统的半衰期约为30秒,而在组织中最长可达15至30分钟。相比较血管紧张素Ⅱ而言,血管紧张素Ⅲ(七肽)仍具有40%的升压活性和100%的促醛固酮分泌活性。血管紧张素Ⅳ(六肽)与血管紧张素Ⅲ相似,而活性更低。Template:Angiotensin receptor modulators(英语:Template:Angiotensin receptor modulators)
相关
- 去颤去颤(defibrillation),也称除颤,是指对于危及生命的心律不整(cardiac dysrhythmias)、心室颤动(ventricular fibrillation)、无脉性心室频脉(Pulseless VT(英语:Pulseless VT))一种常见的
- 头孢氨芐头孢氨苄(英语:Cefalexin或英语:Cephalexin,又译先锋霉素Ⅳ、又作赐福力欣、头孢力欣、赐尔复新、西华烈信、施华林、喜化幸、雪华力欣、或赐泛立信等)。是一种半合成的第一代口
- 康德伊曼努尔·康德(德语:Immanuel Kant;德语发音:.mw-parser-output .IPA{font-family:"Charis SIL","Doulos SIL","Linux Libertine","Segoe UI","Lucida Sans Unicode","Code2000
- 东亚日报《东亚日报》(朝鲜语:동아일보/東亞日報)是大韩民国的一家报纸。由韩国的媒体人金性洙、宋镇禹创刊于1920年4月1日。总部位于首尔特别市锺路区。日发行量2,068,647份(韩国发行公
- Carl Jung卡尔·古斯塔夫·荣格(Carl Gustav Jung,1875年7月26日-1961年6月6日),瑞士心理学家、精神科医师,分析心理学的创始者。荣格出生于瑞士一个凯斯威尔的村庄。荣格六个月大时,家庭移
- GPnotebook家庭医生笔记(英语:GPnotebook)是英国为家庭医生(GP)所建的医学数据库。它是一本线上医学百科全书,提供全球临床医师立即的参考资源。家庭医生笔记数据库内建有超过三万篇资料页面
- 语言接触语言接触(language contact)是一个语言学研究的现象,发生在不同的语言系统相互互动或影响之时。此种研究又称接触语言学(contact linguistics)。当不同语言的说话者密切的接触时,
- 急症科人体解剖学 - 人体生理学 组织学 - 胚胎学 人体寄生虫学 - 免疫学 病理学 - 病理生理学 细胞学 - 营养学 流行病学 - 药理学 - 毒理学急诊医学,也被称为急症医学,为医学专科,
- 疏水在化学里,疏水性指的是一个分子与水互相排斥的物理性质。这种分子称为疏水物。疏水性分子偏向于非极性,并因此较会溶解在中性和非极性溶液(如有机溶剂)。疏水性分子在水里通常会
- 谷神星7020939300000000000♠(9.393±0.005)×1020 kg0.290.51 km/s谷神星(Ceres,/ˈsɪəriːz/; 小行星序号:1 Ceres)是在火星和木星轨道之间的主小行星带中最亮的天体。它的直