CYP2D6

2F9Q, 3QM4, 3TBG, 3TDA, 4WNT, 4WNU, 4WNV, 4WNW· iron ion binding · drug binding · arachidonic acid epoxygenase activity · steroid hydroxylase activity · oxidoreductase activity · oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen · oxygen binding · heme binding· mitochondrion · endoplasmic reticulum· steroid metabolic process · coumarin metabolic process · alkaloid metabolic process · alkaloid catabolic process · monoterpenoid metabolic process · drug metabolic process · arachidonic acid metabolic process · isoquinoline alkaloid metabolic process · drug catabolic process · exogenous drug catabolic process · small molecule metabolic process · heterocycle metabolic process · negative regulation of binding · oxidation-reduction process · oxidative demethylation细胞色素 P450 2D6（英语：Cytochrome P450 2D6）是一种由人类CYP2D6基因编码的酶。CYP2D6主要表達在肝脏，并且也表達在中枢神经系统中，包括黑质。CYP2D6是细胞色素P450混合功能氧化酶系统的成员之一，是人体中最重要的代谢酶之一。CYP2D6参与25%的临床药物的代谢和清除，过程主要是O-去甲基化。CYP2D6也参与多种内源性物质的代谢，如5-羟色胺和神经类固醇。EC 1.1/2/3/4/5/6/7/8/9/10/11/12/13/14/15/16/17/18/19/20/21/22  · 2.1/2/3/4/5/6/7(2.7.10/11-12)/8/9  · 3.1/2/3/4(3.4.21/22/23/24)/5/6/7/8/9/10/11/12/13  ·