腺苷脱氨酶抑制剂

1M7M, 3IAR· adenosine deaminase activity · adenosine deaminase activity · adenosine deaminase activity · protein binding · zinc ion binding · zinc ion binding · hydrolase activity· cytoplasm · lysosome · cytosol · plasma membrane · external side of plasma membrane · cell surface · membrane · cell junction · cytoplasmic vesicle · dendrite cytoplasm · neuronal cell body· in utero embryonic development · trophectodermal cell differentiation · liver development · placenta development · germinal center B cell differentiation · positive regulation of germinal center formation · negative regulation of leukocyte migration · negative regulation of mature B cell apoptosis · purine base metabolic process · adenosine catabolic process · adenosine catabolic process · deoxyadenosine catabolic process · cell adhesion · aging · nucleotide metabolic process · purine ribonucleoside monophosphate biosynthetic process · positive regulation of heart rate · positive regulation of B cell proliferation · purine nucleotide salvage · positive regulation of T cell differentiation in thymus · regulation of cell-cell adhesion mediated by integrin · T cell activation · response to hydrogen peroxide · negative regulation of apoptosis · purine-containing compound salvage · regulation of circadian sleep/wake cycle, sleep · positive regulation of smooth muscle contraction · dATP catabolic process · hypoxanthine biosynthetic process · inosine biosynthetic process · inosine biosynthetic process · xanthine biosynthetic process · positive regulation of alpha-beta T cell differentiation · lung alveolus development · Peyer's patch development · embryonic digestive tract development · negative regulation of inflammatory response · positive regulation of calcium-mediated signaling · positive regulation of T cell receptor signaling pathway · nucleobase, nucleoside and nucleotide metabolic process · negative regulation of adenosine receptor signaling pathway · negative regulation of penile erection · negative regulation of thymocyte apoptosis结构 / ECOD结构 / ECOD结构 / ECOD腺苷脱氨酶（英语：Adenosine deaminase）的是一种参与嘌呤代谢作用的酶。它是用作拆解食物组织中的核酸中的腺苷。在人体中，它主要参与了免疫细胞的制造。若该酶突变，会造成T细胞、B细胞及自然杀手细胞皆无法表现的严重复合型免疫缺乏症(SCID)。腺苷脱氨酶对腺苷进行不可逆转的脱氨作用，转化腺苷为相关的核苷肌苷，移除氨基酸组。腺苷脱氨酶的突变基因使之不容易被表达，这是一些严重复合型免疫缺乏症(SCID)的原因。基因突变令ADA被过度产生是溶血性贫血原因之一。有一些证据表明，一个不同的等位基因(ADA2)可能会导致自闭症。ADA活性异常与多种疾病相关，如当人体发生结核杆菌侵袭时，人体主要启动细胞免疫，T淋巴细胞和单核巨噬细胞被分枝杆菌激活可引起ADA的活性增强，且间皮细胞吞噬分枝杆菌后产生的特异性细胞因子亦诱导ADA的活性增强。EC 1.1/2/3/4/5/6/7/8/9/10/11/12/13/14/15/16/17/18/19/20/21/22  · 2.1/2/3/4/5/6/7(2.7.10/11-12)/8/9  · 3.1/2/3/4(3.4.21/22/23/24)/5/6/7/8/9/10/11/12/13  ·IMP→AMP： 腺嘌呤琥珀酸合酶 · 腺苷酸琥珀酸裂解酶 · reverse (AMP deaminase)二氢乳清酸脱氢酶 · 乳清酸核苷-5'-磷酸脱羧酶/尿苷酸合成酶医学导航：遗传代谢缺陷代谢、k,c/g/r/p/y/i,f/h/s/l/o/e,a/u,n,mk,cgrp/y/i,f/h/s/l/o/e,au,n,m,人名体征药物(A16/C10)、中间产物(k,c/g/r/p/y/i,f/h/s/o/e,a/u,n,m)