肌联蛋白

肌联蛋白（肌巨蛋白）（英语：titin）是人体中是由肌联蛋白基因（TTN）编码的蛋白质。肌联蛋白是一个巨大的蛋白质，为肌肉收缩的弹性元件。它由244个结构域以及之间的肽序列连接组成。这些结构域在蛋白拉伸时去折叠，而在张力去除后重新折叠。1BPV, 1G1C, 1NCT, 1NCU, 1TIT, 1TIU, 1TKI, 1TNM, 1TNN, 1WAA, 1YA5, 2A38, 2BK8, 2F8V, 2ILL, 2J8H, 2J8O, 2NZI, 2RQ8, 2WP3, 2WWK, 2WWM, 2Y9R, 3KNB, 3LCY, 3LPW, 3PUC, 3Q5O, 3QP3· nucleic acid binding · protein serine/threonine kinase activity · protein tyrosine kinase activity · calcium ion binding · protein binding · calmodulin binding · ATP binding · structural constituent of muscle · enzyme binding · telethonin binding · identical protein binding · actinin binding · protein self-association · actin filament binding· extracellular region · cytosol · striated muscle thin filament · Z disc · M band· muscle contraction · striated muscle contraction · mitotic chromosome condensation · blood coagulation · muscle filament sliding · platelet activation · skeletal muscle thin filament assembly · skeletal muscle myosin thick filament assembly · sarcomere organization · regulation of protein kinase activity · cardiac muscle fiber development · sarcomerogenesis · regulation of catalytic activity · response to calcium ion · cardiac myofibril assembly肌联蛋白是已知最大的蛋白质，同时肌联蛋白基因也拥有已知的单基因中最多的外显子（363个）。肌联蛋白对横纹肌的收缩很重要，它横跨肌节从Z线到M线的区域，同粗肌丝的装配和位置固定有关。在这个基因的突变能引起肌肉疾病，例如肢带型肌营养不良。肌联蛋白有已知最长的IUPAC命名（如氧的IUPAC命名是oxygen）有18万个字母长。EC 1.1/2/3/4/5/6/7/8/9/10/11/12/13/14/15/16/17/18/19/20/21/22  · 2.1/2/3/4/5/6/7(2.7.10/11-12)/8/9  · 3.1/2/3/4(3.4.21/22/23/24)/5/6/7/8/9/10/11/12/13  ·