1IVO, 1M14, 1M17, 1MOX, 1NQL, 1XKK, 1YY9, 1Z9I, 2EB2, 2EB3, 2GS2, 2GS7, 2ITN, 2ITO, 2ITP, 2ITQ, 2ITT, 2ITU, 2ITV, 2ITW, 2ITX, 2ITY, 2ITZ, 2J5E, 2J5F, 2J6M, 2JIT, 2JIU, 2JIV, 2KS1, 2M0B, 2M20, 2RF9, 2RFD, 2RFE, 2RGP, 3B2U, 3B2V, 3BEL, 3BUO, 3C09, 3G5V, 3G5Y, 3GOP, 3GT8, 3IKA, 3LZB, 3NJP, 3OB2, 3OP0, 3P0Y, 3PFV, 3POZ, 3QWQ, 3UG1, 3UG2, 3VJN, 3VJO, 3VRP, 3VRR, 3W2O, 3W2P, 3W2Q, 3W2R, 3W2S, 3W32, 3W33, 4G5J, 4G5P, 4HJO, 4I1Z, 4I20, 4I21, 4I22, 4I23, 4I24, 4JQ7, 4JQ8, 4JR3, 4JRV, 4KRL, 4KRM, 4KRO, 4KRP, 4LI5, 4LL0
· MAP kinase kinase kinase activity
· protein tyrosine kinase activity
· transmembrane receptor protein tyrosine kinase activity
· receptor signaling protein tyrosine kinase activity
· transmembrane signaling receptor activity
· epidermal growth factor-activated receptor activity
· protein binding
· ATP binding
· enzyme binding
· protein phosphatase binding
· nitric-oxide synthase regulator activity
· identical protein binding
· protein heterodimerization activity
· extracellular space
· nucleus
· cytoplasm
· endosome
· endoplasmic reticulum membrane
· plasma membrane
· endosome membrane
· membrane
· integral to membrane
· basolateral plasma membrane
· AP-2 adaptor complex
· nuclear membrane
· membrane raft
· perinuclear region of cytoplasm
· activation of MAPKK activity
· ossification
· embryonic placenta development
· hair follicle development
· response to stress
· signal transduction
· cell surface receptor signaling pathway
· epidermal growth factor receptor signaling pathway
· activation of phospholipase C activity
· axon guidance
· salivary gland morphogenesis
· cell proliferation
· positive regulation of cell proliferation
· fibroblast growth factor receptor signaling pathway
· cell-cell adhesion
· cerebral cortex cell migration
· positive regulation of cell migration
· positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S
· positive regulation of catenin import into nucleus
· negative regulation of epidermal growth factor receptor signaling pathway
· negative regulation of protein catabolic process
· positive regulation of phosphorylation
· activation of phospholipase A2 activity by calcium-mediated signaling
· negative regulation of apoptotic process
· positive regulation of MAP kinase activity
· innate immune response
· positive regulation of nitric oxide biosynthetic process
· positive regulation of DNA repair
· positive regulation of DNA replication
· protein autophosphorylation
· neurotrophin TRK receptor signaling pathway
· phosphatidylinositol-mediated signaling
· positive regulation of fibroblast proliferation
· digestive tract morphogenesis
· positive regulation of epithelial cell proliferation
· regulation of peptidyl-tyrosine phosphorylation
· regulation of nitric-oxide synthase activity
· protein insertion into membrane
· positive regulation of protein kinase B signaling cascade
· morphogenesis of an epithelial fold
表皮生长因子受体（英语：epidermal growth factor receptor，简称为EGFR、ErbB-1或HER1）是一类名为表皮生长因子家族（EGF-家族）的细胞外蛋白配体的细胞表面受体 。
表皮生长因子受体是ErbB受体家族家族的成员之一，ErbB家族是包含四种紧密联系蛋白的亚家族，这四种蛋白分别是受体酪氨酸激酶类：EGFR（ErbB-1）、HER2/c-neu（ErbB-2）、Her 3（ErbB-3）以及Her 4（ErbB-4）。影响EGFR表达或活性的突变可能导致癌症。
表皮生长因子及其受体是由范德堡大学的斯坦利·科恩发现的，科恩与丽塔·列维-蒙塔尔奇尼因发现生长因子类而共同获得了1986年诺贝尔生理学或医学奖。
表皮生长因子受体（EGFR）存在于细胞表面且因结合特异性受体而被激活，这些受体包括表皮生长因子和转化生长因子-α。ErbB2并无已知的直接激活配体，可能结构性地处于激活状态，或在与如EGFR等其他家族成员形成异源二聚体时被激活。
· 2.1/2/3/4/5/6/7(2.7.10/11-12)/8/9 · 3.1/2/3/4(3.4.21/22/23/24)/5/6/7/8/9/10/11/12/13 ·
医学导航: 肿瘤
基因/标志
肿瘤/同名/附瘤
药物 (L1i/1e/V03)
神经生长因子受体：高亲和力Trk受体 (TrkA, TrkB, TrkC)
肝细胞生长因子受体（英语：C-Met）
Somatomedin（胰岛素样生长因子1受体）
ErbB/表皮生长因子受体
