LIF

1EMR, 1PVH, 2Q7N· receptor binding · cytokine activity · leukemia inhibitory factor receptor binding· immune response · multicellular organismal development · embryo implantation · positive regulation of cell proliferation · negative regulation of cell proliferation · stem cell maintenance · positive regulation of peptidyl-serine phosphorylation · positive regulation of peptidyl-serine phosphorylation of STAT protein · tyrosine phosphorylation of Stat3 protein · positive regulation of tyrosine phosphorylation of Stat1 protein · positive regulation of tyrosine phosphorylation of Stat3 protein · positive regulation of MAPK cascade · positive regulation of macrophage differentiation · negative regulation of meiosis · positive regulation of transcription from RNA polymerase II promoter · decidualization · negative regulation of hormone secretion · lung alveolus development · muscle organ morphogenesis · neuron development · positive regulation of astrocyte differentiation · leukemia inhibitory factor signaling pathway · positive regulation of peptidyl-tyrosine phosphorylation · lung vasculature development · lung lobe morphogenesis · trophoblast giant cell differentiation · spongiotrophoblast differentiation · negative regulation of ERK1 and ERK2 cascade · positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis · regulation of metanephric nephron tubule epithelial cell differentiation · positive regulation of protein localization to nucleus白血病抑制因子（Leukemia inhibitory factor，缩写 LIF）是一种属于白介素-6（英语：interleukin 6）大类的细胞因子。它能通过抑制分化影响细胞生长。LIF水平下降会使细胞开始分化。白血病抑制因子能够诱导骨髓性白血病细胞的末端分化，进而阻止其生长，因而得名。白血病抑制因子还有以下功能：能促进多种细胞的生长与分化，影响骨代谢、恶病质体、神经发育（英语：Neural development），胚胎发育以及炎症作用。受p53调控的白血病抑制因子能促进小鼠和人的胚胎着床。一篇文章提出重组人白血病抑制因子可能可以提高意外怀孕的妇女（体内胚胎）的着床成功率。LIF在正常情况下会由囊胚中的滋养层（TE）表达，而其受体LIFR则会由内细胞群（ICM）的细胞表达。胚胎干细胞取自内细胞群的细胞，在体外培养时就需要额外补充LIF。目前，重组LIF已可以通过基因工程的手段由植物（水稻）产生。干细胞培养基中大都含有LIF，可用于替代喂养层（feeder layer）细胞，因为喂养层细胞的主要作用即产生LIF。不表达LIF基因的喂养层细胞难以支持干细胞的培养。LIF通过招募信号诱导分子以及转录激活因子3（STAT3）促进细胞的自我更新。活化的LIFR能征募Stat3。随后，JAK激酶能将其磷酸化。不过LIF和Stat3是不足以阻止细胞分化的，一旦移去培养基中的血清，干细胞就会分化。在原生多能性干细胞分化的可逆阶段，加入LIF可以使细胞重回原生多能性阶段。