PTEN

✍ dations ◷ 2025-06-07 03:55:28 #PTEN
1D5R, 2KYL· phosphatidylinositol-3-phosphatase activity · phosphoprotein phosphatase activity · protein serine/threonine phosphatase activity · protein tyrosine phosphatase activity · protein binding · protein tyrosine/serine/threonine phosphatase activity · lipid binding · anaphase-promoting complex binding · phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity · enzyme binding · protein kinase binding · PDZ domain binding · inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity· cytoplasm · cytosol · plasma membrane · internal side of plasma membrane · PML body · myelin sheath adaxonal region · cell projection · neuron projection· angiogenesis · negative regulation of protein phosphorylation · regulation of B cell apoptotic process · protein dephosphorylation · phospholipid metabolic process · phosphatidylinositol biosynthetic process · apoptotic process · induction of apoptosis · activation of mitotic anaphase-promoting complex activity · epidermal growth factor receptor signaling pathway · neuron-neuron synaptic transmission · synapse assembly · central nervous system development · heart development · learning or memory · locomotory behavior · cell proliferation · positive regulation of cell proliferation · negative regulation of cell proliferation · fibroblast growth factor receptor signaling pathway · regulation of neuron projection development · negative regulation of phosphatidylinositol 3-kinase cascade · cell migration · dentate gyrus development · central nervous system neuron axonogenesis · negative regulation of cell migration · negative regulation of myelination · regulation of protein stability · negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S · central nervous system myelin maintenance · regulation of cellular component size · regulation of myeloid cell apoptotic process · multicellular organismal response to stress · social behavior · peptidyl-tyrosine dephosphorylation · maternal behavior · negative regulation of apoptotic process · protein kinase B signaling cascade · endothelial cell migration · inositol phosphate metabolic process · small molecule metabolic process · innate immune response · locomotor rhythm · negative regulation of cell size · negative regulation of organ growth · inositol phosphate dephosphorylation · phosphatidylinositol dephosphorylation · neurotrophin TRK receptor signaling pathway · phosphatidylinositol-mediated signaling · cardiac muscle tissue development · forebrain morphogenesis · brain morphogenesis · negative regulation of epithelial cell proliferation · negative regulation of axonogenesis · protein stabilization · T cell receptor signaling pathway · positive regulation of sequence-specific DNA binding transcription factor activity · negative regulation of focal adhesion assembly · negative regulation of protein kinase B signaling cascade · rhythmic synaptic transmission · canonical Wnt receptor signaling pathway · synapse maturation · prepulse inhibition · male mating behavior · long-term synaptic potentiation · prostate gland growth · dendritic spine morphogenesis · negative regulation of dendritic spine morphogenesis · negative regulation of ribosome biogenesis · negative regulation of cell aging · negative regulation of excitatory postsynaptic membrane potential · presynaptic membrane assembly · postsynaptic density assembly · positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process · negative regulation of G1/S transition of mitotic cell cycle · positive regulation of excitatory postsynaptic membrane potential磷酸酯酶与张力蛋白同源物(英语:Phosphatase and tensin homolog,简称为PTEN)是一种在人体中由PTEN基因编码的蛋白质。该基因的突变是多种癌症进展过程的环节之一。PTEN通过其磷酸酯酶蛋白产物而行使一种抑癌基因的作用。这一磷酸酯酶参与了细胞周期的调节,阻止细胞过快地生长与分裂。其为癌微RNAMIRN21的靶之一。该基因被鉴定为一种肿瘤抑制物,在多种癌症中往往处于变异状态。该基因编码的蛋白质是一种磷脂酰肌醇-3,4,5-三磷酸3-磷酸酯酶。该蛋白同时含有一张力蛋白样结构域及一催化结构域,这与双特异性蛋白酪氨酸磷酸酶很相似。但与大部分蛋白质酪氨酸磷酸酶不同的是,该蛋白偏好脱去磷酸肌醇底物上的磷酸。该蛋白负性调控胞内磷脂酰肌醇-3,4,5-三磷酸的水平,并通过负性调控Akt/PKB信号通道发挥抑癌基因的作用。PTEN (基因)引用了美国国家医学图书馆提供的资料,这些资料属于公共领域。Template:蛋白酪氨酸磷酸酶类脂酶(胆盐依赖性脂酶、胃脂肪酶/舌脂肪酶、胰脂肪酶、溶酶体酸性脂肪酶、激素敏感性脂肪酶、内皮脂肪酶、肝脂肪酶、脂蛋白脂肪酶、单酰基甘油脂肪酶、二酰基甘油脂肪酶)磷脂酶(A1、A2、B)EC 1.1/2/3/4/5/6/7/8/9/10/11/12/13/14/15/16/17/18/19/20/21/22  · 2.1/2/3/4/5/6/7(2.7.10/11-12)/8/9  · 3.1/2/3/4(3.4.21/22/23/24)/5/6/7/8/9/10/11/12/13  ·医学导航: 肿瘤基因/标志肿瘤/同名/附瘤药物 (L1i/1e/V03)

相关

  • DPGN弥漫增生性肾小球肾炎(Diffuse proliferative glomerulonephritis、DPGN)是一种肾小球肾炎(Glomerulonephritis)的类型、归为SLE之肾脏病变最严重的形式、也是最常见的,发生
  • 人体肌肉骨骼系统人体肌肉骨骼系统或肌肉骨骼系统,简称肌骨系统(英语:Human musculoskeletal system,也作locomotor system,曾称activity system)是一种器官系统,通过为人体提供结构、支撑、稳定、
  • 阿基斯二世阿基斯二世(古希腊语:Ἄγις B', 英语:Agis II),(?-前399年),前427年—前399年在位,斯巴达埃乌吕彭家族国王,阿基达姆斯二世之子及继承人。公元前426年与公元前425年的阿基达姆斯战
  • 罗莎琳·富兰克林罗莎琳·爱尔西·富兰克林(英语:Rosalind Elsie Franklin,1920年7月25日-1958年4月16日),是一位英国物理化学家与晶体学家。她所做的研究,专注于DNA、病毒、煤炭与石墨等物质的结构
  • 宏观宏观这名词,通常用来描述,那些可以被肉眼测量与观察的物体。当用在现象或抽象物体(abstract object)时,则是描述,我们所能理解,存在于这世界上的。通常被认为是宏观的长度尺度,大致
  • 农学农学,狭义上专指农艺学(英语:Agronomy)是研究与农作物生产相关领域的科学,包括作物生长发育规律及其与外界环境条件的关系、病虫害防治、土壤与营养、种植制度、遗传育种等领域。
  • Hsub2/subSeOsub4/sub硒酸是一种无机酸,化学式为H2SeO4。它是硒的含氧酸,它的结构可以更准确地被描述为(HO)2SeO2。根据价层电子对互斥理论的推测,中心的硒是四面体的,其中Se-O键长为161pm。在固态,它
  • 铁器铁器是以铁为主要金属的一种器物类型,铁质自然界中含铁数量颇多。然而其融熔温度在摄氏一千度以上故早期人类无法锻造。直到精致炭及鼓风技术发明后才逐渐应用。目前最早使用
  • 马卢尔县马卢尔县(英语:Malheur County,发音: /mælˈhɪər/)是美国俄勒冈州东南部的一个县,东隔蛇河与爱达荷州相望,南邻内华达州。马卢尔县亦是组成东俄勒冈的八个县份之一。马卢尔县面
  • 英国城市列表英国城市列表列出英国各城市(City)。由英国君主赐予城市地位(City status)的地方才可称为“城市”。直至2016年,英国共有69座城市,英格兰占其51,北爱尔兰占其5,苏格兰占其7,威尔士占