2W96, 2W99, 2W9F, 2W9Z
· protein binding
· cyclin-dependent protein serine/threonine kinase regulator activity
· enzyme binding
· protein kinase binding
· intracellular
· nucleus
· nucleoplasm
· cytosol
· tight junction
· G1/S transition of mitotic cell cycle
· S phase of mitotic cell cycle
· mitotic cell cycle
· re-entry into mitotic cell cycle
· liver development
· positive regulation of protein phosphorylation
· response to DNA damage stimulus
· lactation
· response to iron ion
· response to X-ray
· response to organic nitrogen
· negative regulation of Wnt receptor signaling pathway
· negative regulation of epithelial cell differentiation
· endoplasmic reticulum unfolded protein response
· organ regeneration
· mitotic G1 DNA damage checkpoint
· response to magnesium ion
· response to vitamin E
· Leydig cell differentiation
· mammary gland epithelial cell proliferation
· positive regulation of mammary gland epithelial cell proliferation
· response to drug
· response to estrogen stimulus
· fat cell differentiation
· response to ethanol
· positive regulation of cyclin-dependent protein kinase activity
· cell division
· response to corticosterone stimulus
· response to calcium ion
· canonical Wnt receptor signaling pathway
· mammary gland alveolus development
· response to UV-A
G1/S-特异性周期蛋白-D1是一个由人类基因所编码的蛋白质。
该基因编码的蛋白质属于高度保守的周期蛋白家族，该家族成员的显著特征是贯穿细胞周期，其蛋白质丰度周期性地急剧改变。周期蛋白作为CDK（周期蛋白依赖性激酶）的调节因子。不同的周期蛋白表现出各自独特的表达及降解特性，这有助于每个有丝分裂事件在时间上的协调性。周期蛋白D1这种亚型的周期蛋白与CDK4或CDK6形成复合物并作为它们的调节亚基，这两种周期蛋白依赖性激酶对于G1到S期的转变来说是不可或缺的。该蛋白表现出与抑癌基因Rb有着相互作用，且此基因的表达受Rb的正向调控。周期蛋白D1发生突变、扩增及过表达将会改变细胞周期进程，这些现象常发生在多种肿瘤中并可能导致肿瘤发生。
使用周期蛋白D1进行免疫组化染色可用于诊断套细胞淋巴瘤。
