首页 >
多巴胺接收器 Dsub2/sub
✍ dations ◷ 2025-06-28 12:03:41 #多巴胺接收器 D<sub>2</sub>
6CM4181313489ENSG00000149295ENSMUSG00000032259P14416P61168NM_016574、NM_000795、XM_017017296NM_010077、XM_006509996NP_000786、NP_057658、XP_016872785NP_000786.1NP_034207、XP_006510059多巴胺受体D2(Dopamine receptor D2,简称D2R),为翻译自 DRD2 基因的一种多巴胺受体蛋白。D2R最早于1975年为Philip Seeman(英语:Philip Seeman)所发现,并将其命名为“抗精神疾患性多巴胺受体”(antipsychotic dopamine receptor)。D2R为所有抗精神病药物的作用标的。D2R属于一种多巴胺受体(英语:dopamine receptor),并会与Gi结合。Gi为G蛋白偶联受体的一种亚型,会抑制腺苷酸环化酶的活性。在小鼠模式中,齿状回(英语:dentate gyrus)的neuronal calcium sensor-1(英语:neuronal calcium sensor-1)(NCS-1)会影响D2R在细胞膜的表现量。这项机制会影响突触可塑性及记忆形成。在苍蝇模式中,多巴胺性神经元上的D2R自体受器(英语:autoreceptor)能避免神经元死亡,进而引发类帕金森病的症状。Alternative splicing of this gene results in three transcript variants encoding different isoform(英语:isoform)s.The long form (D2Lh) has the "canonical" sequence and functions as a classic post-synaptic receptor.The short form (D2Sh) is pre-synaptic and functions as an autoreceptor(英语:autoreceptor) that regulates the levels of dopamine in the synaptic cleft.Agonism of D2sh receptors inhibits dopamine release; antagonism increases dopaminergic(英语:dopaminergic) release.A third D2(Longer) form differs from the canonical sequence where 270V is replaced by VVQ.等位基因变异:Some researchers have previously associated the polymorphism Taq 1A (rs1800497) to the DRD2 gene.
However, the polymorphism resides in exon 8 of the ANKK1(英语:ANKK1) gene.DRD2 TaqIA polymorphism has been reported to be associated with an increased risk for developing motor
fluctuations but not hallucinations in Parkinson's disease.Most of the older antipsychotic drugs such as chlorpromazine and haloperidol are antagonists for the dopamine D2 receptor, but are, in general, very unselective, at best selective only for the "D2-like family" receptors and so binding to D2, D3 and D4, and often also to many other receptors such as those for serotonin and histamine, resulting in a range of side-effects and making them poor agents for scientific research. In similar manner, older dopamine agonists used for Parkinson's disease such as bromocriptine and cabergoline(英语:cabergoline) are poorly selective for one dopamine receptor over another, and, although most of these agents do act as D2 agonists, they affect other subtypes as well. Several selective D2 ligands are, however, now available, and this number is likely to increase as further research progresses.The dopamine receptor D2 has been shown to interact with EPB41L1(英语:EPB41L1),PPP1R9B(英语:PPP1R9B)and NCS-1(英语:NCS-1).The D2 receptor forms receptor heterodimers(英语:GPCR oligomer) in vivo (in living animals) with other G protein-coupled receptors; these include:The D2 receptor has been shown to form hetorodimers in vitro (and possibly in vivo) with DRD3(英语:Dopamine D3 receptor),DRD5(英语:Dopamine receptor D5),and 5-HT2A(英语:5-HT2A receptor).多巴胺受体D2引用了美国国家医学图书馆提供的数据,这些数据属于公共领域。Template:Dopaminergics
相关
- 腺嘌呤腺嘌呤(英语:Adenine,简称A,旧称维生素B4)是一种嘌呤,在生物化学上具有许多不同的功用。于细胞呼吸中,是以富有能量的腺苷三磷酸(ATP),以及辅因子烟酰胺腺嘌呤二核苷酸(NAD)、黄素腺嘌呤
- 乙丙橡胶乙丙橡胶,有机化合物制品,是橡胶制品工业中一项极为重要的原材料,有多种良好的理化特性。乙丙橡胶又可分为二元乙丙、三元乙丙橡胶、改性乙丙和热塑性乙丙。而三元乙丙橡胶(EPD
- 商业名称商业名称(trade name, trading name, or business name),又称为商号、交易名称或营业名称等,是企业在从事商业活动时所使用的名称,功能类似于品牌。可指企业名、商品名或商标名等
- 太空生物学天体生物学(英语:astrobiology),旧称外空生物学(xenobiology),是一门研究在宇宙中生命起源、生物演化、分布和未来发展的交叉学科,并不只限于地外生物,或包括对地球生物的研究。在天
- 删除删除(delete)可能指:
- 偷工减料偷工减料,常是贪污或收贿的具体象征,常与伪造文书同时发生。例如:伪造探勘纪录、伪造工程材料检验报告、伪造验收纪录……等。
- 蠼螋蠼螋(拼音:qú sōu,注音:ㄑㄩˊ ㄙㄡ,南京官话:qü2sou1,粤拼:keoi4 sau1,其俱切、所鳩切,音同“渠搜”),俗称“耳夹子虫”,属昆虫类的有翅亚纲革翅目,此类昆虫目前已记录的有12科,约2000
- 居鲁士您要查找的居鲁士可能是:
- 印度系文字婆罗米系文字或印度系文字,是印度孔雀王朝的婆罗米文衍生而来的一种书写系统,属于元音附标文字(Abugida)。其被广泛使用于南亚、东南亚、部分中亚及东亚地区。是目前世界上第四
- 沈曾植沈曾植(1850年-1922年11月20日),字子培,号巽斋,别号乙盫,晚号寐叟,浙江省嘉兴府嘉兴县人,沈维鐈孙,蒙元史地学者、书法家、史学家、同光体诗人,“于学无所不窥”,朴学宗师。据《沈曾植年