1BF5, 1YVL, 2KA6
· RNA polymerase II core promoter sequence-specific DNA binding
· RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity
· double-stranded DNA binding
· sequence-specific DNA binding transcription factor activity
· signal transducer activity
· tumor necrosis factor receptor binding
· calcium ion binding
· protein binding
· enzyme binding
· nucleus
· nucleoplasm
· nucleolus
· cytoplasm
· cytosol
· axon
· negative regulation of endothelial cell proliferation
· positive regulation of mesenchymal cell proliferation
· negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
· regulation of transcription from RNA polymerase II promoter
· induction of apoptosis
· JAK-STAT cascade
· blood circulation
· negative regulation of angiogenesis
· virus-host interaction
· cytokine-mediated signaling pathway
· lipopolysaccharide-mediated signaling pathway
· tumor necrosis factor-mediated signaling pathway
· response to cytokine stimulus
· cellular response to interferon-beta
· regulation of apoptotic process
· negative regulation of I-kappaB kinase/NF-kappaB cascade
· response to exogenous dsRNA
· response to peptide hormone stimulus
· endothelial cell migration
· positive regulation of transcription, DNA-dependent
· positive regulation of transcription from RNA polymerase II promoter
· positive regulation of smooth muscle cell proliferation
· response to cAMP
· defense response to virus
· interferon-gamma-mediated signaling pathway
· regulation of interferon-gamma-mediated signaling pathway
· type I interferon-mediated signaling pathway
· regulation of type I interferon-mediated signaling pathway
· JAK-STAT cascade involved in growth hormone signaling pathway
· renal tubule development
· metanephric mesenchymal cell proliferation involved in metanephros development
· metanephric mesenchymal cell differentiation
STAT1是转录因子中信号转导及转录激活蛋白（STAT蛋白）家族的一员。STAT1涉及I型、II型或III型干扰素激活基因的正调控。在干扰素-γ刺激下，STAT1会组成同源二聚体或与STAT3组成异二聚体结合到GAS（Interferon-Gamma-Activated Sequence，干扰素γ激活序列）启动子上；而在干扰素-α或干扰素-β刺激下，STAT1会与STAT2组成异二聚体结合到ISRE（Interferon-Stimulated Response Element，干扰素激活反应元件）启动子上。在这两种情况下，STAT二聚体与启动子的结合都会导致ISG（Interferon-Stimulated Genes，干扰素激活基因）的表达。
Expression of STAT1 can be induced with diallyl disulfide, a compound in garlic.
STAT1能与下列蛋白质发生相互作用：
